New research may explain the mechanism by which a ketogenic diet (such as the Atkins diet) is able to control epilepsy in about half of epileptics. In this study, researchers found that leptin administered directly to the brain or nasal epithelium significantly inhibited seizures. The authors concluded that leptin-triggered signaling may be a key to how a ketogenic diet combats epilepsy.
J Clin Invest. Published online 2007 December 20.